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Publications
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ChiRhoClin,
Inc. Sponsored Secretin
Studies for Diagnostic Use
New Secretin Studies
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Draganov P, Patel A, Fazel A, Toskes P, Forsmark C.
(2005, July). Prospective evaluation of
the accuracy of the intraductal secretin stimulation test in the
diagnosis of chronic pancreatitis. Clin Gastroenterol
Hepatol. 3(7):695-9.
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Pollack BJ, Grendell JH.
Where have all the dreiling tubes gone?
Am J
Gastroenterol. 2006 Feb;101(2):356-9.
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Stevens T, Conwell DL, Zuccaro G Jr, Van Lente F, Purich
E, Khandwala F, Fein S.
A randomized crossover study of secretin-stimulated endoscopic and
dreiling tube pancreatic function test methods in healthy subjects.
Am J Gastroenterol. 2006 Feb;101(2):351-5.
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Hirschowitz BI, Simmons JL, Johnson LF, Mohnen J. (2004,
Mar). Risk factors for esophagitis in extreme
acid hypersecretors with and without Zollinger-Ellison syndrome.
Clin Gastroenterol Hepatol;2(3):220-9.
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Moumakwa BA, Crawley CD, Purich E, Edinboro L, Karnes
HT. (2005, Jan). Use of capillary
electrophoresis in drug quality assessment of synthetic porcine
secretin. Biomed Chromatogr. ;19(1):68-79.
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Stevens T, Conwell DL, Zuccaro G, Van Lente F, Khandwala
F, Purich E, Vargo JJ, Fein S, Dumot JA, Trolli P, O'Laughlin C.
Electrolyte composition of
endoscopically collected duodenal drainage fluid after synthetic porcine
secretin stimulation in healthy subjects. Gastrointest
Endosc. 2004 Sep;60(3):351-5.
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Chey WY, Chang TM. Secretin, 100
years later. J Gastroenterol. 2003;38(11):1025-35. Review.
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Conwell DL, Zuccaro G Jr, Vargo JJ, Trolli PA, Vanlente
F, Obuchowski N, Dumot JA, O'laughlin C. An
endoscopic pancreatic function test with synthetic porcine secretin for
the evaluation of chronic abdominal pain and suspected chronic
pancreatitis. Gastrointest Endosc. 2003 Jan;57(1):37-40.
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Devereaux BM, Fein S, Purich E, Trout JR, Lehman GA,
Fogel EL, Phillips S, Etemad R, Jowell P, Toskes PP, Sherman S.
A new synthetic porcine secretin for
facilitation of cannulation of the dorsal pancreatic duct at ERCP in
patients with pancreas divisum: a multicenter, randomized, double-blind
comparative study. Gastrointest Endosc. 2003 May;57(6):643-7.
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New Advances in Preventing ERCP Induced Pancreatitis.
John.Baillie.PDF.file
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Secretin Imaging and Publications
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Merkel E.
Secretin-Stimulated MRCP.
Gastroenterology & Hepatology 2005 1(3)
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Matos C, Bali MA, Delhaye M, Deviere J.
Magnetic resonance imaging in the detection of pancreatitis and
pancreatic neoplasms.
Best Pract Res Clin Gastroenterol. 2006 Feb;20(1):157-78
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Gillams AR, Kurzawinski T, Lees WR.
Diagnosis of duct disruption and assessment of pancreatic leak with
dynamic secretin-stimulated MR cholangiopancreatography.
AJR Am J Roentgenol. 2006 Feb;186(2):499-506.
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Erturk SM, Ichikawa T, Motosugi U, Sou H, Araki T.
Diffusion-weighted MR imaging in the evaluation of pancreatic exocrine
function before and after secretin stimulation.
Am J Gastroenterol. 2006 Jan;101(1):133-6.
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Matos C, Coppens E.
[Chronic and inflammatory pancreatitis: role of cross-sectional imaging]
J Radiol. 2005 Jun;86(6 Pt 2):749-57; quiz 758. Review. French.
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Merkle EM, Baillie J.
Exocrine pancreatic function: evaluation with MR imaging before and
after secretin stimulation.
Am J Gastroenterol. 2006 Jan;101(1):137-8.
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Bali MA, Sztantics A, Metens T, Arvanitakis M, Delhaye
M, Deviere J, Matos C. Quantification
of pancreatic exocrine function with secretin-enhanced magnetic
resonance cholangiopancreatography: normal values and short-term effects
of pancreatic duct drainage procedures in chronic pancreatitis. Initial
results. Eur Radiol. 2005 Oct;15(10):2110-21. Epub 2005
Jul 1.
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Czako L, Takacs T, Morvay Z, Csernay L, Lonovics J.
[Diagnostic value of secretin-enhanced magnetic resonance
cholangiopancreatography (S-MRCP) after unsuccessful endoscopic
retrograde cholangiopancreatography (ERCP)] Orv Hetil.
2004 Mar 7;145(10):529-34. Hungarian
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Matos C, Winant C, Delhaye M, Deviere J.
Functional MRCP in pancreatic and periampullary disease.
Int J Gastrointest Cancer. 2001;30(1-2):5-18. Review
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Hellund JC, Geitung JT, Meo AM, Angelsen JH, Munkvik M,
Trondsen E, Buanes T.
[Secretin stimulated magnetic resonance cholangiopancreatography in
diseases of the biliary and pancreatic ducts] Tidsskr Nor
Laegeforen. 2002 Mar 10;122(7):691-4. Norwegian.
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Manfredi R, Brizi MG, Tancioni V, Vecchioli A, Marano P.
Magnetic resonance pancreatography (MRP): morphology and function.
Rays. 2001 Apr-Jun;26(2):127-33. Review.
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Manfredi R, Brizi MG, Costamagna G, Masselli G,
Vecchioli Scaldazza A, Marano P.
Pancreas divisum and santorinicele: assessment by dynamic magnetic
resonance cholangiopancreatography during secretin stimulation.
Radiol Med (Torino). 2002 Jan-Feb;103(1-2):55-64. English,
Italian.
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Czako L, Endes J, Takacs T, Boda K, Lonovics J.
Evaluation of pancreatic exocrine function by secretin-enhanced magnetic
resonance cholangiopancreatography.
Pancreas. 2001 Oct;23(3):323-8.
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Matos C, Metens T, Deviere J, Delhaye M, Le Moine O,
Cremer M.
Pancreas divisum: evaluation with secretin-enhanced magnetic resonance
cholangiopancreatography. Gastrointest Endosc. 2001
Jun;53(7):728-33.
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Manfredi R, Costamagna G, Brizi MG, Spina S, Maresca G,
Vecchioli A, Mutignani M, Marano P.
Pancreas divisum and "santorinicele": diagnosis with dynamic MR
cholangiopancreatography with secretin stimulation.
Radiology. 2000 Nov;217(2):403-8.
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Past Studies
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Somogyi L, Cintron M, Toskes PP.
Synthetic porcine secretin is highly
accurate in pancreatic function testing in individuals with chronic
pancreatitis. Pancreas. 2000 Oct;21(3):262-5.
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Jowell PS, Robuck-Mangum G, Mergener
K, Branch MS, Purich ED, Fein SH.
A double-blind, randomized, dose response
study testing the pharmacological efficacy of synthetic porcine secretin.
Aliment Pharmacol Ther. 2000 Dec;14(12):1679-84.
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Metz DC, Buchanan M, Purich E, Fein
S. A randomized controlled
crossover study comparing synthetic porcine and human secretins with
biologically derived porcine secretin to diagnose Zollinger-Ellison
Syndrome. Aliment Pharmacol Ther. 2001 May;15(5):669-76.
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Devereaux BM, Lehman GA, Fein S,
Phillips S, Fogel EL, Sherman S.
Facilitation of pancreatic duct
cannulation using a new synthetic porcine secretin. Am J
Gastroenterol. 2002 Sep;97(9):2279-81.
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Preliminary Observations of A Randomized 2-Way
Crossover Study Comparing the Endoscopic Pancreatic Function Test (ePFT)
with Secretin for Exocrine Pancreas Function With and Without Meperidine
/ Midazolam Sedation in normal Subjects.
Conwell.Purich.PDF.file
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A randomized 2-WAY Cross-over Study Comparing the
Effects Of Conscious Sedation and Analgesia On Exocrine Pancreas
Function In Normal Healthy Subjects (HS)
Conwell.PDF.file
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A New Endoscopic Pancreatic
Function Test (ePFT) Using Synthetic Porcine Secretin in the Evaluation
of Chronic Abdominal Pain (CAP) and Suspected Chronic Pancreatitis (CP).
An abstract from Digestive Disease Week, San Francisco 2002.
Conwell.PDF
file
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National Institutes of Health
(NIH) State of the Science conference Statement, Endoscopic Retrograde
Cholangiopancreatography (ERCP) for Diagnosis and Therapy, January
14-16, 2002.
NIH
Conference.PDF file
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Other Clinical
Studies for Investigational Drugs Synthetic Human and Porcine Secretin
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Toda Y, Mori K, Hashimoto T, Miyazaki M, Nozaki S,
Watanabe Y, Kuroda Y, Kagami S.
Administration of secretin for autism alters dopamine metabolism in the
central nervous system.
Brain Dev. 2006 Mar;28(2):99-103. Epub 2005 Sep 15.
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Coplan J, Souders MC, Mulberg AE, Belchic JK, Wray J,
Jawad AF, Gallagher PR, Mitchell R, Gerdes M, Levy SE.
Children with autistic spectrum disorders. II:
parents are unable to distinguish secretin from placebo under
double-blind conditions. Arch Dis Child. 2003
Aug;88(8):737-9.
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Levy SE, Souders MC, Wray J, Jawad AF, Gallagher PR,
Coplan J, Belchic JK, Gerdes M, Mitchell R, Mulberg AE.
Children with autistic spectrum disorders. I:
comparison of placebo and single dose of human synthetic secretin.
Arch Dis Child. 2003 Aug;88(8):731-6.
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Molloy CA, Manning-Courtney P, Swayne S, Bean J, Brown
JM, Murray DS, Kinsman AM, Brasington M, Ulrich CD 2nd.
Lack of benefit of intravenous synthetic
human secretin in the treatment of autism. J Autism Dev
Disord. 2002 Dec;32(6):545-51.
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Unis AS, Munson JA, Rogers SJ, Goldson E, Osterling J,
Gabriels R, Abbott RD, Dawson G.
A randomized, double-blind,
placebo-controlled trial of porcine versus synthetic secretin for
reducing symptoms of autism. J Am Acad Child Adolesc
Psychiatry. 2002 Nov;41(11):1315-21.
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Sandler AD, Sutton KA, DeWeese J,
Girardi MA, Sheppard V, Bodfish JW. Lack
of benefit of a single dose of synthetic human secretin in the treatment
of autism and pervasive developmental disorder. N Engl J
Med. 1999 Dec 9;341(24):1801-6.
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A Randomized, Double-Blind,
Placebo-Controlled Trial of Porcine Versus Synthetic Secretin for
Reducing Symptoms of Autism.
Unis.PDF file
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Raimondo M, Imoto M, DiMagno EP.
Rapid endoscopic secretin stimulation
test and discrimination of chronic pancreatitis and pancreatic cancer
from disease controls. Clin Gastroenterol Hepatol. 2003
Sep;1(5):397-403.
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Additional publications will be
posted as published.
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