Finding a test with sensitivity and specificity in early detection of pancreatic disease and dysfunction is imperative to helping the patient population.
The two-sample ePFT – we recently reported the validity of a shortened, two-sample collection method in which samples are collected at 30 and 45 minutes after secretin administration. This method retains a high sensitivity for detecting pancreatic exocrine insufficiency and is ideal for screening patients in whom there is a low suspicion of pancreatic disease. The two-sample ePFT also serves as a useful adjunct to advanced endoscopic procedures such as endoscopic retrograde cholangiopancreatography and EUS. Patients with borderline or equivocal two-sample ePFT results should be considered for the 1-hour five-sample collection method.