EUS and ePFT for Gastroenterologists

Solution

The two-sample ePFT – we recently reported the validity of a shortened, two-sample collection method in which samples are collected at 30 and 45 minutes after secretin administration. This method retains a high sensitivity for detecting pancreatic exocrine insufficiency and is ideal for screening patients in whom there is a low suspicion of pancreatic disease. The two-sample ePFT also serves as a useful adjunct to advanced endoscopic procedures such as endoscopic retrograde cholangiopancreatography and EUS. Patients with borderline or equivocal two-sample ePFT results should be considered for the 1-hour five-sample collection method.

Early Detection of Pancreatic Cancer: Risk Factors and the Current State of Screening Modalities

Secretin is indicated for the following:

Diagnosis of Gastrinoma

Stimulation of gastrin secretion to aid in the diagnosis of gastrinoma.

Diagnosis of pancreatic dysfunction

Stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction.

Endoscopic retrograde cholangiopancreatography

Stimulation of pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography.

Source: EUS and secretin endoscopic pancreatic function test predict evolution to overt structural changes of chronic pancreatitis in patients with nondiagnostic baseline imaging – PMC (nih.gov)